Methods
Choosing a cell atlas without choosing your conclusion
A practical checklist for tissue coverage, donor structure, annotation depth, and replication.
Read noteNotes from the analytical work.
Practical guidance on public data, model assumptions, and the details that decide whether a result reproduces.
Rare variants
What gene constraint can and cannot say
Constraint is strong population evidence, but it is not a disease mechanism by itself.
Read notePhenotypes
When an ontology release changes your result
Version drift can alter term relationships and ranking behavior. Here is how we audit it.
Read noteSingle cell
Building a negative-control signature library
Common stress, cell-cycle, interferon, and dissociation programs belong in every enrichment workflow.
Read noteInterpretation
Why we prefer an evidence graph to one score
One number hides disagreement. A graph preserves which evidence supports each step.
Read noteOpen science
A minimum provenance record for public data
Source accessions, versions, transformations, exclusions, and checks every analysis should retain.
Read note