Ingest with provenance
Every source enters with accession, release, licensing context, cohort metadata, and file identity.
An analysis is only as strong as its audit trail.
REELD workflows are designed to be reconstructed, challenged, and transferred across public datasets.
Harmonize explicitly
Gene identifiers, cell labels, phenotype terms, and reference builds are mapped with retained ambiguity.
Model the question
Analyses are built around a named mechanism and its plausible competing explanations.
Integrate evidence
Genomic, cellular, and phenotype layers remain visible inside one evidence graph.
Stress test
We vary datasets, parameters, ontology rules, controls, and label resolution.
Release reproducibly
Code, environment locks, manifests, and limitations travel with every release-ready output.
What accompanies a release-ready analysis
A result without its analytical context is not portable.
Source manifestAccessions, versions, licenses, and exclusions
Environment lockPackages, references, and execution context
Sensitivity reportAlternate parameters, datasets, and negative controls
Interpretation memoClaim, uncertainty, alternatives, and next experiment
Need a methods review?
We can help pressure-test a rare-disease analysis before it becomes a mechanistic claim.